Objectives
The overall aim of this project is to investigate how pathogen-induced inflammation affects the
development of glucose intolerance in obese subjects.
Our research objectives are formulated as follows:
1. To investigate how VAT-infection of obese mice affects the development of insulin resistance and glucose intolerance.
2. To elucidate which cell subsets play a role in pathogen-induced VAT-inflammation and how these cells affect the onset of insulin resistance and glucose intolerance.
3. To compare the number and phenotype of leukocytes in VAT of obese and obese diabetic human patients, with or without seropositivity for CMV.